P1c peptide decorated liposome targeting αvβ3-expressing tumor cellsin vitroandin vivo
نویسندگان
چکیده
منابع مشابه
Multimodality tumor imaging targeting integrin αvβ3
The cell adhesion molecule integrin αvβ3 is an important player in the process of tumor angiogenesis and metastasis. Antibodies, peptides, peptidomimetics, and small molecule antagonists against integrin αvβ3 have been shown to induce endothelial apoptosis, to inhibit tumor angiogenesis, and to increase endothelial permeability. The ability to quantitatively image integrin αvβ3 expression in vi...
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E. Kluza, I. Jacobs, S. J. Hectors, K. H. Mayo, A. W. Griffioen, G. J. Strijkers, and K. Nicolay Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States, Angiogenesis Laboratory, Department of Medical Oncology, VU Medical Cen...
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BACKGROUND AND METHODS Paclitaxel, a widely used antitumor agent, has limited clinical application due to its hydrophobicity and systemic toxicity. To achieve sustained and targeted delivery of paclitaxel to tumor sites, liposomes composed of egg phosphatidylcholine, cholesterol, and distearolyphosphatidyl ethanolamine-N-poly(ethylene glycol) (PEG(2000)) were prepared by a lipid film method. In...
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BACKGROUND The neurotrophic receptor tyrosine kinase B (TrkB) has diverse signaling roles in neurons and tumor cells. Accordingly, its suppressive targeting is of interest in neuroblastoma and other tumors, whereas its role in improving survival is focused in neurons. Here we describe targeting of TrkB-binding peptide-conjugated liposomes (PCL) to the TrkB-expressing mouse macrophage-like cell ...
متن کاملSession: P1C
the superiority of the quadratic images to second harmonic (SH) images in phantoms, both in terms of spatial and contrast resolutions. Furthermore, we have shown that the quadratic images produce contrast-to-tissue ratios (CTRs) at the same level of those produced by pulse inversion (PI) without the need for multiple transmission. The imaging results have also shown that quadratic imaging also ...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2018
ISSN: 2046-2069
DOI: 10.1039/c8ra05014g